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Benzophenone Basic information

description Chemical Properties application Uses indicator Toxicity Production method

Product Name:	Benzophenone
Synonyms:	BENZOPHENONE, 99%BENZOPHENONE, 99%BENZOPHENONE, 99%BENZOPHENONE, 99%;erbnejiatong;Dimenhydrinate EP Impurity J(Benzophenone);Diphenhydramine Impurity 5（Diphenhydramine EP Impurity E）;Dimenhydrinate EP Impurity J;photo sensitizer BP;Pipenzolate Impurity 2(Benzophenone);Benzophenone whatsapp+86 19930203281
CAS:	119-61-9
MF:	C13H10O
MW:	182.22
EINECS:	204-337-6
Mol File:	119-61-9.mol

Benzophenone Chemical Properties

Melting point	47-51 °C(lit.)
Boiling point	305 °C(lit.)
density	1.11
vapor density	4.21 (vs air)
vapor pressure	1 mm Hg ( 108 °C)
FEMA	2134 \| BENZOPHENONE
refractive index	1.5893
Fp	>230 °F
storage temp.	Refrigerator
solubility	ethanol: soluble100mg/mL, clear, colorless (80% ethanol)
form	Crystalline Powder or Flakes
color	White to off-white
Odor	Characteristic.
Water Solubility	insoluble (<0.1 g/100 mL at 25 ºC)
JECFA Number	831
Merck	14,1098
BRN	1238185
Stability:	Stable. Incompatible with strong oxidizing agents, strong reducing agents. Combustible.
InChIKey	RWCCWEUUXYIKHB-UHFFFAOYSA-N
CAS DataBase Reference	119-61-9(CAS DataBase Reference)
NIST Chemistry Reference	Benzophenone(119-61-9)
EPA Substance Registry System	Benzophenone (119-61-9)

Benzophenone Safety Information

Hazard Codes	Xi,N,Xn,F
Risk Statements	36/37/38-52/53-50/53-67-65-62-51/53-48/20-11-40
Safety Statements	26-61-37/39-29-60-36-62-36/37-33-16-9
RIDADR	UN 3077 9/PG 3
WGK Germany	2
RTECS	DI9950000
F	10
TSCA	Yes
HazardClass	9
PackingGroup	III
HS Code	29143900
Hazardous Substances Data	119-61-9(Hazardous Substances Data)
Toxicity	LD50 orally in Rabbit: > 10000 mg/kg LD50 dermal Rabbit 3535 mg/kg

Benzophenone Usage And Synthesis

Toxicity	GRAS(FEMA)。 LD502897mg/kg(Mice, orally)。
Production method	There are different methods. 1. Condensation of benzyl chloride and benzene , and then by nitric acid oxidation. 2. The condensation of benzene and carbon tetrachloride, and then by hydrolysis. In the laboratory, the production is based on aluminum chloride as a catalyst, prepared by reacting benzene with benzoyl chloride.3.Condensation of benzene and benzoyl chloride in the presence of aluminum chloride, and then crystallized from ethanol.
Chemical Properties	Orange Crystals
Chemical Properties	Benzophenone is a combustible, white, crystalline solid with a rose-like odor
Uses	It is used in the manufacturing of antihistamines, hypnotics, insecticides.
Uses	Reported to bind monsaccharides in the presence of polysaccharides
Uses	Benzophenone is used as a synthetic intermediate for manufacture of pharmaceuticals and agricultural chemicals. It is also used as a photoinitiator in UV-curable printing inks, as a fragrance in perfumes, as a flavor enhancer in foods. Benzophenone can be added as a UV-absorbing agent to plastics, lacquers, and coatings at concentrations of 2–8%.
Production Methods	Benzophenone is commercially synthesized by the atmospheric oxidation of diphenylmethane using a catalyst of copper naphthenate. Alternatively, it can be produced by a Friedel–Crafts acylation of benzene using either benzoyl chloride or phosgene in the presence of aluminum chloride .
Preparation	By Friedel–Craft condensation of benzene with benzoyl chloride in the presence of aluminum chloride.
Carcinogenicity	Lifetime dermal carcinogenicity studies in mice and rabbits did not show any tumor excess in the treated animals. Female Swiss mice and New Zealand White rabbits of both sexes were treated dermally with 0, 5, 25, or 50% of benzophenone (0.02 mL) twice a week for 120 or 180 weeks. Weekly examination of the rabbits did not reveal any reduction in survival or appearance of tumors. Mice treated with benzophenone did not show any excess in the number of tumor-bearing animals or in total number of tumors compared to untreated control animals. Although three skin tumors were observed in the benzophenone- treated mice (one case of squamous cell carcinoma and two cases of squamous cell papilloma), there were also three tumors (one carcinoma and toe papillomas) observed in the control animals.

Benzophenone Preparation Products And Raw materials

Raw materials

Benzene-->Aluminium chloride-->Carbon tetrachloride-->Benzoyl chloride-->PHOSGENE-->Aluminium chloride hexahydrate

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